NOX5
Fonksiyon
NOX5, süperoksit üreten yeni bir NADPH oksidazdır. [1]
Nox5, c-abl ile etkileşime girer, süperoksit üretimi c- abl'nin fosforilasyonuna neden olur. Eğer c-abl kinaz aktivitesi engellenirse, Nox5 süperoksit üretimi de engellenir. [3]
Kaynakça
- "Entrez Gene: NOX5 NADPH oxidase, EF-hand calcium binding domain 5". 5 Aralık 2010 tarihinde kaynağından arşivlendi.
- "A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes". J. Biol. Chem. 276 (40): 37594-601. Ekim 2001. doi:10.1074/jbc.M103034200. PMID 11483596.
- "NOVEL REDOX-DEPENDENT REGULATION OF NOX5 BY THE TYROSINE KINASE C-ABL". Free Radic. Biol. Med. 44 (5): 868-81. Mart 2008. doi:10.1016/j.freeradbiomed.2007.11.020. PMC 2278123 $2. PMID 18160052.
Konuyla ilgili yayınlar
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- Cheng G, Cao Z, Xu X, ve diğerleri. (2001). "Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5". Gene. 269 (1–2): 131-40. doi:10.1016/S0378-1119(01)00449-8. PMID 11376945.
- Bánfi B, Molnár G, Maturana A, ve diğerleri. (2001). "A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes". J. Biol. Chem. 276 (40): 37594-601. doi:10.1074/jbc.M103034200. PMID 11483596. Geçersiz
|doi-access=free(yardım) - Armstrong JS, Bivalacqua TJ, Chamulitrat W, ve diğerleri. (2002). "A comparison of the NADPH oxidase in human sperm and white blood cells". Int. J. Androl. 25 (4): 223-9. doi:10.1046/j.1365-2605.2002.00351.x. PMID 12121572.
- Moskwa P, Dagher MC, Paclet MH, ve diğerleri. (2002). "Participation of Rac GTPase activating proteins in the deactivation of the phagocytic NADPH oxidase". Biochemistry. 41 (34): 10710-6. doi:10.1021/bi0257033. PMID 12186557.
- Ota T, Suzuki Y, Nishikawa T, ve diğerleri. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Geçersiz
|doi-access=free(yardım) - Bánfi B, Tirone F, Durussel I, ve diğerleri. (2004). "Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5)". J. Biol. Chem. 279 (18): 18583-91. doi:10.1074/jbc.M310268200. PMID 14982937. Geçersiz
|doi-access=free(yardım) - Jana A, Pahan K (2005). "Human Immunodeficiency Virus Type 1 gp120 Induces Apoptosis in Human Primary Neurons through Redox-Regulated Activation of Neutral Sphingomyelinase". J. Neurosci. 24 (43): 9531-40. doi:10.1523/JNEUROSCI.3085-04.2004. PMC 1955476 $2. PMID 15509740.
- Kawahara T, Ritsick D, Cheng G, Lambeth JD (2005). "Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation". J. Biol. Chem. 280 (36): 31859-69. doi:10.1074/jbc.M501882200. PMID 15994299. Geçersiz
|doi-access=free(yardım) - Femling JK, Nauseef WM, Weiss JP (2005). "Synergy between extracellular group IIA phospholipase A2 and phagocyte NADPH oxidase in digestion of phospholipids of Staphylococcus aureus ingested by human neutrophils". J. Immunol. 175 (7): 4653-61. doi:10.4049/jimmunol.175.7.4653. PMID 16177112. Geçersiz
|doi-access=free(yardım) - Cucoranu I, Clempus R, Dikalova A, ve diğerleri. (2005). "NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts". Circ. Res. 97 (9): 900-7. doi:10.1161/01.RES.0000187457.24338.3D. PMID 16179589. Geçersiz
|doi-access=free(yardım) - Kamiguti AS, Serrander L, Lin K, ve diğerleri. (2006). "Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia". J. Immunol. 175 (12): 8424-30. doi:10.4049/jimmunol.175.12.8424. PMID 16339585. Geçersiz
|doi-access=free(yardım) - Fu X, Beer DG, Behar J, ve diğerleri. (2006). "cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells". J. Biol. Chem. 281 (29): 20368-82. doi:10.1074/jbc.M603353200. PMID 16707484. Geçersiz
|doi-access=free(yardım) - Duerrschmidt N, Stielow C, Muller G, ve diğerleri. (2006). "NO-mediated regulation of NAD(P)H oxidase by laminar shear stress in human endothelial cells". J. Physiol. 576 (Pt 2): 557-67. doi:10.1113/jphysiol.2006.111070. PMC 1890367 $2. PMID 16873416.
- Chenevier-Gobeaux C, Lemarechal H, Bonnefont-Rousselot D, ve diğerleri. (2007). "Superoxide production and NADPH oxidase expression in human rheumatoid synovial cells: regulation by interleukin-1beta and tumour necrosis factor-alpha". Inflamm. Res. 55 (11): 483-90. doi:10.1007/s00011-006-6036-8. PMID 17122966.
- Jagnandan D, Church JE, Banfi B, ve diğerleri. (2007). "Novel mechanism of activation of NADPH oxidase 5. calcium sensitization via phosphorylation". J. Biol. Chem. 282 (9): 6494-507. doi:10.1074/jbc.M608966200. PMID 17164239. Geçersiz
|doi-access=free(yardım) - BelAiba RS, Djordjevic T, Petry A, ve diğerleri. (2007). "NOX5 variants are functionally active in endothelial cells". Free Radic. Biol. Med. 42 (4): 446-59. doi:10.1016/j.freeradbiomed.2006.10.054. PMID 17275676.
- Tirone F, Cox JA (2007). "NADPH oxidase 5 (NOX5) interacts with and is regulated by calmodulin". FEBS Lett. 581 (6): 1202-8. doi:10.1016/j.febslet.2007.02.047. PMID 17346712.
- Qin F, Simeone M, Patel R (2007). "Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction". Free Radic. Biol. Med. 43 (2): 271-81. doi:10.1016/j.freeradbiomed.2007.04.021. PMID 17603936.
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