NOX4

NADPH oxidaz 4, insanlarda NOX4 ile kodlanan ve NADPH oksidazların NOX ailesine üye enzim.[1]

Fonksiyon

Oksijen algılama, tüm aerobik organizmalarda homeostaz için gereklidir. Nötrofil granülositlerdeki büyük miktarlarda reaktif oksijen türlerinin (ROS) üretiminden sorumlu olana benzer bir fagosit tipi oksidazın böbrekte, böbrek korteksindeki eritropoietin sentezini düzenleyen bir oksijen sensörü olarak işlev gördüğü ileri sürülmüştür.[1]

Nox4, damar sistemini inflamatuvar strese karşı korur. [2] Amino endoperoksitler tarafından Nox bağımlı reaktif oksijen türü modülasyonu, yüksek Nox4 eksprese eden kanser hücrelerinde apoptozu indükleyebilir. [3]

Kaynakça

1. "Entrez Gene: NOX4 NADPH oxidase 4". 2 Kasım 2008 tarihinde kaynağından arşivlendi.
2. "Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase". Circ. Res. 110 (9): 1217-25. Nisan 2012. doi:10.1161/CIRCRESAHA.112.267054. PMID 22456182.
3. "Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells". Cell Death Dis. 4 (3): e552. Mart 2013. doi:10.1038/cddis.2013.68. PMC 3615744 $2. PMID 23519121.

Konuyla ilgili yayınlar

 

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